Acetylsalicylic Acid Gastro-resistant Tablets IP 325mg

An IP-standard enteric-coated antiplatelet tablet (325mg) indicated for long-term protection against heart attacks, ischemic strokes, and arterial blood clots. Its gastro-resistant coating bypasses the stomach to prevent gastric ulcers while permanently blocking Thromboxane A2 to suppress platelet aggregation.

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Acetylsalicylic Acid (Aspirin) Gastro-resistant Tablets IP — 325mg

Acetylsalicylic Acid Gastro-resistant Tablets IP are formulated in strict compliance with Indian Pharmacopoeia (IP) standards, providing a standard 325mg strength of pure acetylsalicylic acid (Aspirin).

Featuring a specialized gastro-resistant (enteric) coating, these tablets are engineered to pass through the stomach completely intact. They dissolve only upon reaching the alkaline environment of the small intestine, significantly reducing localized gastric mucosal irritation, stomach upsets, and the risk of acid-induced ulcers during long-term therapy.

Core Clinical Indications

Vascular Prophylaxis: Primary and secondary prevention of thrombotic cardiovascular and cerebrovascular diseases.
Acute Myocardial Infarction (Heart Attack): Secondary prevention of re-infarction and reduction of mortality risk post-infarction.
Ischemic Stroke & TIA Management: Reduces the risk of recurrent ischemic strokes and Transient Ischemic Attacks (TIAs) in high-risk patients.
Mild-to-Moderate Pain & Inflammation: Management of chronic inflammatory arthritic conditions or acute mild-to-moderate somatic pain.

Mechanism of Action

Acetylsalicylic acid acts as a powerful antiplatelet and anti-inflammatory agent through structural enzyme modification:

It irreversibly acetylates the active site of the Cyclooxygenase-1 (COX-1) enzyme inside blood platelets.
This specific action permanently blocks the synthesis of Thromboxane A2 ( $TXA_2$ ), a potent chemical factor that triggers platelet aggregation and arterial vasoconstriction.
Because blood platelets lack cellular nuclei, they cannot synthesize new enzymes. Consequently, a single 325mg dose suppresses platelet clotting mechanics for their entire 7 to 10-day lifespan.

Product Specifications

Attribute	Specification
Active Ingredient	Acetylsalicylic Acid IP (325mg)
Therapeutic Class	Antiplatelet / Non-Steroidal Anti-Inflammatory Drug (NSAID)
Tablet Feature	Enteric-Coated / Gastro-resistant
Packaging Variant	Moisture-proof Blister or Alu-Alu strips
Storage Conditions	Store in a dry place below 25°C. Protect from direct light.

Dosage & Administration Guidelines

📋 Usage Guideline: Tablets must be swallowed whole with water and never crushed, chewed, or broken, as destroying the enteric coating will cause direct stomach irritation. For routine cardioprotection, it is typically taken once daily at the exact same time, or as precisely directed by a registered medical practitioner.

Contraindications & Critical Warnings

⚠️ WARNING: Strictly contraindicated in patients with active peptic ulcers, hemophilia, or other bleeding disorders, and those with known hypersensitivity to NSAIDs.

🚫 REYE'S SYNDROME ALERT: Do not administer to children or adolescents under the age of 19 recovering from viral infections (such as chickenpox or flu) due to the risk of Reye's Syndrome—a rare but potentially fatal condition causing acute brain and liver swelling.