Acenocoumarol Tablets IP 2 mg

An IP-standard oral anticoagulant tablet (2mg) that blocks Vitamin K-dependent clotting factors to prevent deep vein thrombosis, pulmonary embolism, and thromboembolic strokes. It demands highly individualized dosing guided by regular blood $INR$ tracking.

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Acenocoumarol Tablets IP — 2mg

Acenocoumarol Tablets IP are a high-precision oral anticoagulant medication formulated in strict compliance with Indian Pharmacopoeia standards. Containing 2mg of pure acenocoumarol per tablet, this potent Vitamin K antagonist is vital for preventing the formation of hazardous blood clots in blood vessels.

Core Clinical Indications

Thromboembolic Disorders: Prophylaxis and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Atrial Fibrillation (AF): Prevention of thromboembolic strokes in patients suffering from chronic atrial fibrillation.
Cardiac Valve Replacement: Long-term anticoagulation management following mechanical or prosthetic heart valve replacements.

Mechanism of Action

Acenocoumarol interferes with the hepatic synthesis of blood clotting mechanisms:

It competitively inhibits the Vitamin K epoxide reductase enzyme system.
This blockage prevents the reduction of Vitamin K, halting the gamma-carboxylation of Vitamin K-dependent clotting factors: Factors II, VII, IX, and X.
By reducing these active clotting factors, it lengthens clotting time, measured clinically via the International Normalized Ratio ( $INR$ ).

Product Specifications

Attribute	Specification
Active Ingredient	Acenocoumarol IP (2mg)
Therapeutic Class	Oral Anticoagulant (Coumarin Derivative)
Dosage Form	Tablet (Often with cross-scores for precise splitting)
Storage	Store below 30°C in a cool, dry place. Protect from light.

Dosage & Critical Safety Monitoring

📋 Routine INR Monitoring Required: Acenocoumarol has a narrow therapeutic window. The dosage is highly individualized and adjusted daily based on periodic Prothrombin Time ( $PT$ ) / INR blood tests. Tablets should be taken at the exact same time every single day.

⚠️ WARNING: High risk of bleeding complications. This drug is strictly contraindicated during pregnancy (causes fetal harm) and in patients with active severe bleeding, severe hypertension, or severe liver/kidney impairment. Patients must inform their doctor about all concurrent medications and dietary Vitamin K intake to prevent toxic drug interactions.