Ambrisentan Tablets 10mg

A selective Endothelin Type-A receptor antagonist tablet (10mg) indicated for once-daily management of Pulmonary Arterial Hypertension (PAH). It works by blocking severe lung vessel constriction to lower pulmonary arterial pressure, enhance exercise capacity, and delay clinical worsening.

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Ambrisentan Tablets — 10mg

Ambrisentan Tablets 10mg are a high-precision, oral cardiovascular medication formulated to deliver a strong, targeted therapeutic effect. Classified as a highly selective Endothelin Receptor Antagonist (ERA), this once-daily medication is crucial for managing specific forms of arterial hypertension within the lungs, helping to significantly improve exercise capacity and slow down disease progression.

Core Clinical Indications

Pulmonary Arterial Hypertension (PAH): Indicated for the treatment of Pulmonary Arterial Hypertension (WHO Group 1) in adult patients to improve exercise ability and delay clinical worsening.
Combination Therapy: Frequently co-administered alongside phosphodiesterase-5 (PDE-5) inhibitors (such as Tadalafil) to provide a dual-pathway approach for superior long-term outcomes.

Mechanism of Action

Ambrisentan acts as a powerful vasodilator by targeting the biochemical pathways that cause blood vessels to constrict:

It serves as a highly selective antagonist for the Endothelin Type-A ( $E_A$ ) receptor.
By binding to $E_A$ receptors on vascular smooth muscle cells, it blocks the action of Endothelin-1—a potent endogenous peptide responsible for severe vasoconstriction and blood vessel remodeling in the lungs.
Crucially, it leaves the Endothelin Type-B ( $E_B$ ) receptor largely unaffected, allowing it to continue clearing endothelin from the blood and promoting the release of natural vasodilators like nitric oxide.

Product Specifications

Attribute	Specification
Active Ingredient	Ambrisentan (10mg)
Therapeutic Class	Endothelin Receptor Antagonist (ERA)
Dosage Form	Film-Coated, Oblong Tablet
Packaging Variant	Moisture-barrier blister packs or Alu-Alu strips
Storage Conditions	Store at room temperature between 20°C and 25°C. Keep protected from light and moisture.

Dosage & Administration Guidelines

📋 Usage Guideline: The standard therapeutic dose is 10mg taken orally once daily, with or without food. Tablets must be swallowed completely whole and should never be split, crushed, or chewed. Dosing should be carefully managed by a specialist experienced in PAH management.

Contraindications & Critical Safety Warnings

🚼 EMBRYO-FETAL TOXICITY WARNING: Ambrisentan is highly teratogenic and strictly contraindicated during pregnancy. It can cause severe birth defects if administered to a pregnant woman. Female patients of childbearing potential must undergo mandatory monthly pregnancy testing and use highly effective dual contraception methods throughout treatment.

🩸 Hepatic Monitoring: While Ambrisentan carries a lower risk of liver injury compared to older ERAs, baseline liver function tests (LFTs) should be evaluated prior to initiation and monitored periodically as a clinical precaution.