Tranexamic Acid 500mg and Mefenamic Acid 250mg Tablets

Tranexamic Acid & Mefenamic Acid Tablets (500mg / 250mg)

This prescription medication combines two powerful therapeutic agents to deliver a comprehensive approach to managing heavy and painful menstrual periods (Menorrhagia and Dysmenorrhea).

While Tranexamic Acid works efficiently to control and reduce excessive blood loss, Mefenamic Acid targets acute pelvic pain and uterine cramping, allowing patients to resume regular daily activities with comfort.

Dual-Action Mechanism

This formulation addresses the underlying physiological causes of heavy, painful cycles through two distinct pathways:

• Fibrinolytic Inhibition (Tranexamic Acid - 500mg): Acts as an anti-fibrinolytic agent. It temporarily prevents the breakdown of blood clots in the uterine lining by blocking plasminogen activation. This directly stabilizes clots and reduces menstrual blood loss by up to 40–50% without altering normal hormonal balance.

• Prostaglandin Synthesis Inhibition (Mefenamic Acid - 250mg): A potent Non-Steroidal Anti-Inflammatory Drug (NSAID). It blocks the cyclooxygenase ($COX$) enzymes to inhibit the production of prostaglandins—the chemical messengers responsible for causing painful uterine contractions, inflammation, and cramping.

Core Clinical Indications

• Acute Menorrhagia: Management of heavy menstrual bleeding due to dysfunctional uterine bleeding ($DUB$).

• Primary & Secondary Dysmenorrhea: Relief of severe abdominal pain, localized cramps, and backache associated with the menstrual cycle.

• Post-Surgical/IUD Induced Bleeding: Management of localized bleeding and cramping sometimes triggered by Intrauterine Device ($IUD$) insertion.

Product Specifications

Dosage & Administration Guidelines

📋 Strict Clinical Administration: This tablet is intended for short-term use only during actual menstrual days. The typical adult dosage is one tablet taken 2 to 3 times a day starting on the first day of heavy bleeding, or as precisely directed by a registered medical practitioner. Always consume after meals to minimize potential gastrointestinal discomfort.

Contraindications & Precautions

⚠️ WARNING: This medication is strictly contraindicated in patients with a history of active thromboembolic disease (such as deep vein thrombosis, pulmonary embolism, or stroke). It should be used with extreme caution in individuals with impaired renal function, active peptic ulcers, or known hypersensitivity to NSAIDs/Aspirin.